Skip to main content
Publications | Persons | Institutes | Projects
[ report an error in this record ]basket (0): add | show Print this page

Synthesis and cytotoxic evaluation of analogues of the marine pyridoacridine amphimedine
Brahic, C.; Darro, F.; Belloir, M.; Bastide, J.; Kiss, R.; Delfourne, E. (2002). Synthesis and cytotoxic evaluation of analogues of the marine pyridoacridine amphimedine. Bioorg. Med. Chem. 10(9): 2845-2853. https://hdl.handle.net/10.1016/S0968-0896(02)00148-7
In: Bioorganic & Medicinal Chemistry. Elsevier: Amsterdam. ISSN 0968-0896; e-ISSN 1464-3391, more
Peer reviewed article  

Available in  Authors 

Keyword
    Marine/Coastal

Authors  Top 
  • Brahic, C.
  • Darro, F.
  • Belloir, M.
  • Bastide, J.
  • Kiss, R., more
  • Delfourne, E.

Abstract
    4-Substituted-7H-pyrido-[4,3,2-de][1,8] or [1,9]-phenanthroline-7-ones and 9-methyl-1,4-diazanaphtacene-3,10-dione, analogues of the marine pyridoacridine amphimedine were synthesised from isoquinoline-5,8-dione. The first compounds were obtained starting from a Diels–Alder reaction whereas the synthesis of the last compound was initiated by a reaction of condensation with 2-aminoacetophenone. The different tetra- and pentacyclic compounds were evaluated for in vitro cytotoxic activities against six distinct human cancer cell lines. All the compounds exhibit cytotoxic activity with IC50 values (i.e., the drug concentration inhibiting the mean growth value of the six cell lines by 50%)<10−7 M for two of them.

All data in the Integrated Marine Information System (IMIS) is subject to the VLIZ privacy policy Top | Authors