Skip to main content
Publications | Persons | Institutes | Projects
[ report an error in this record ]basket (0): add | show Print this page

Synthesis and characterization of the antitumor activities of analogues of meridine, a marine pyridoacridine alkaloid
Delfourne, E.; Darro, F.; Bontemps-Subielos, N.; Decaestecker, C.; Bastide, J.; Frydman, A.; Kiss, R. (2001). Synthesis and characterization of the antitumor activities of analogues of meridine, a marine pyridoacridine alkaloid. J. Med. Chem. 44(20): 3275-3282. https://hdl.handle.net/10.1021/jm0108496
In: Journal of Medicinal Chemistry. American Chemical Society: Easton. ISSN 0022-2623; e-ISSN 1520-4804, more
Peer reviewed article  

Available in  Authors 

Keyword
    Marine/Coastal

Authors  Top 
  • Delfourne, E.
  • Darro, F.
  • Bontemps-Subielos, N.
  • Decaestecker, C.
  • Bastide, J.
  • Frydman, A.
  • Kiss, R., more

Abstract
    Marine compounds with pyridoacridine skeletons are known to exhibit interesting antitumor activities. Among these compounds, meridine has already been reported as having significant antitumor activities in vitro. We synthesized 24 analogues of meridine substituted on ring A with the aim of obtaining compounds that display significantly higher in vitro antitumor activities than meridine. The 24 compounds and meridine used as a control compound were tested at 6 different concentrations on 12 different human cancer cell lines including various histopathological types (glioblastomas and breast, colon, lung, prostate, and bladder cancers). The IC50 value (i.e., the drug concentration inhibiting the mean growth value of the 12 cell lines by 50%) of these 25 compounds ranged over 5 log concentrations, i.e., between 10 and 0.0001 μM, with four of the compounds exhibiting a significantly higher in vitro antitumor activity than meridine. These compounds will now be subjected to further pharmacological investigation including in vivo testing on both conventional murine tumors and human tumors grafted onto nude mice.

All data in the Integrated Marine Information System (IMIS) is subject to the VLIZ privacy policy Top | Authors