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Short term fasting does not aggravate immunosuppression in harbour seals (Phoca vitulina) with high body burdens of organochlorines
de Swart, R.L.; Ross, P.S.; Timmerman, H.H.; Hijman, W.C.; De Ruiter, E.; Liem, A.K.D.; Brouwer, A.; van Loveren, H.; Reijnders, P.J.H.; Vos, J.G.; Osterhaus, A.D.M.E. (1995). Short term fasting does not aggravate immunosuppression in harbour seals (Phoca vitulina) with high body burdens of organochlorines, in: de Swart, R.L. Impaired immunity in seals exposed to bioaccumulated environmental contaminants = Immuunsuppressie in zeehonden blootgesteld aan in de voedselketen geaccumuleerde milieuvervuilende stoffen. pp. 95-110
In: de Swart, R.L. (1995). Impaired immunity in seals exposed to bioaccumulated environmental contaminants = Immuunsuppressie in zeehonden blootgesteld aan in de voedselketen geaccumuleerde milieuvervuilende stoffen. PhD Thesis. Erasmus Universiteit Rotterdam: Rotterdam. ISBN 90-9008419-3. 140 pp., more
Related to:
de Swart, R.L.; Ross, P.S.; Timmerman, H.H.; Hijman, W.C.; De Ruiter, E.; Liem, A.K.D.; Brouwer, A.; van Loveren, H.; Reijnders, P.J.H.; Vos, J.G.; Osterhaus, A.D.M.E. (1995). Short term fasting does not aggravate immunosuppression in harbour seals (Phoca vitulina) with high body burdens of organochlorines. Chemosphere 31(10): 4289-4306, more

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Keywords
    Phoca vitulina Linnaeus, 1758 [WoRMS]
    Marine/Coastal

Authors  Top 
  • de Swart, R.L.
  • Ross, P.S.
  • Timmerman, H.H.
  • Hijman, W.C.
  • De Ruiter, E.
  • Liem, A.K.D.
  • Brouwer, A.
  • van Loveren, H.
  • Reijnders, P.J.H., more
  • Vos, J.G.
  • Osterhaus, A.D.M.E.

Abstract
    Two groups of 11 harbour seals (Phoca vitulina) with different body burdens of organochlorines were subjected to an experimental 15-day fasting period, during which they lost an average 16.5% of their body weights. Blood levels of the most persistent organochlorines showed an approximate twofold increase, while levels of aryl hydrocarbon receptor-binding organochlorines remained largely unaffected. Few differences in immunological parameters were observed between the two dietary groups. Numbers of circulating lymphocytes dropped to about 65% of the initial values and NK cell activity showed a slight increase in both groups. Mitogen- and antigen-induced lymphoproliferative responses of the Baltic group of seals remained within normal ranges. These results suggest that relatively short-term fasting periods do not present an additional immunotoxicological risk to seals with high body burdens of organochlorines.

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