Large-scale biotechnological production of the antileukemic marine natural product sorbicillactone A
Bringmann, G.; Gulder, T.A.M.; Lang, G.; Schmitt, S.; Stöhr, R.; Wiese, J.; Nagel, K.; Imhoff, J.F. (2007). Large-scale biotechnological production of the antileukemic marine natural product sorbicillactone A. Mar. Drugs 5(2): 23-30. https://dx.doi.org/10.3390/md502023
In: Marine Drugs. Molecular Diversity Preservation International (MDPI): Basel. ISSN 1660-3397; e-ISSN 1660-3397, more
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| Authors | | Top |
- Bringmann, G.
- Gulder, T.A.M.
- Lang, G.
- Schmitt, S.
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- Stöhr, R.
- Wiese, J.
- Nagel, K.
- Imhoff, J.F., more
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| Abstract |
In the search for novel bioactive compounds from sponge-derived microorganisms, we have recently identified two structurally and biosynthetically unprecedented fungal metabolites, the novel-type alkaloids sorbicillactone A and sorbicillactone B. Sorbicillactone A is active against leukemia cells without showing notable cytotoxicity. Therefore, we have developed an efficient process for its biotechnological production and isolation on a large scale supplying sufficient material for the ongoing preclinical investigations and structure-activity relationship (SAR) studies. |
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