TRPV1 as a key determinant in ciguatera and neurotoxic shellfish poisoning
Cuypers, E.; Yanagihara, A.; Rainier, J.D.; Tytgat, J. (2007). TRPV1 as a key determinant in ciguatera and neurotoxic shellfish poisoning. Biochem. Biophys. Res. Commun. 361(1): 214-217. dx.doi.org/10.1016/j.bbrc.2007.07.009
In: Biochemical and Biophysical Research Communications. ACADEMIC PRESS INC ELSEVIER SCIENCE: San Diego etc.. ISSN 0006-291X; e-ISSN 1090-2104, more
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| Keywords |
Diseases > Human diseases > Ciguatera
Diseases > Human diseases > Paralytic shellfish poisoning
Marine/Coastal |
| Author keywords |
TRPV1; gambierol; brevetoxin; ciguatera fish poisoning; neurotoxicshellfish poisoning |
| Authors | | Top |
- Cuypers, E., more
- Yanagihara, A.
- Rainier, J.D.
- Tytgat, J., more
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| Abstract |
Ciguatera fish poisoning and neurotoxic shellfish poisoning are distinct clinical entities characterized by gastrointestinal and neurological disturbances, following the consumption of certain reef fish and shellfish containing toxic polyether compounds sporadically present in certain toxic marine dinoflagellates. The biotransformation and bioaccumulation of gambierol and brevetoxin, and their congeners, are believed to be involved in the pathogenesis of these "food-chain diseases", for which no effective treatments are available. Here, we describe for the first time the potent effect of gambierol and brevetoxin on TRPV1 channels, a key player in thermal and pain sensation. Our findings may lead to promising new therapeutic interventions. |
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