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| one publication added to basket [257624] |
Effects of micro-algae commonly used in aquaculture on acyl-homoserine lactone quorum sensing
Natrah, F.M.I.; Kenmegne, M.M.; Wiyoto, W.; Sorgeloos, P.; Bossier, P.; Defoirdt, T. (2011). Effects of micro-algae commonly used in aquaculture on acyl-homoserine lactone quorum sensing. Aquaculture 317(1-4): 53-57. https://dx.doi.org/10.1016/j.aquaculture.2011.04.038
In: Aquaculture. Elsevier: Amsterdam; London; New York; Oxford; Tokyo. ISSN 0044-8486; e-ISSN 1873-5622
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| Trefwoorden |
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| Author keywords |
Quorum sensing; Micro-algae; Quorum sensing interference; Luminescentvibrios |
| Auteurs | | Top |
- Natrah, F.M.I.
- Kenmegne, M.M.
- Wiyoto, W.
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- Sorgeloos, P.
- Bossier, P.
- Defoirdt, T.
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| Abstract |
Quorum sensing, bacterial cell-to-cell communication with small signal molecules such as acyl-homoserine lactones, regulates the virulence of many pathogenic bacteria. Therefore, interfering with quorum sensing is currently being explored as a novel biocontrol strategy to fight bacterial infections. In this study, the effects of 19 micro-algal strains on acyl-homoserine lactone-regulated phenotypes of three reporter strains were investigated. Two freshwater micro-algae inhibited violacein production of quorum sensing reporter strain Chromobacterium violaceum CV026. Further tests using Escherichia coli JB523 showed that micro-algal extracts inhibited or stimulated quorum sensing, depending on the algal strain. One freshwater and five marine algae showed quorum sensing inhibitory activity, whereas two algae stimulated quorum sensing-regulated gene expression. Micro-algal strains that showed inhibitory activity in the previous assays also inhibited acyl-homoserine lactone-regulated bioluminescence in the aquaculture pathogen Vibrio harveyi. The growth of all reporter strains was found to be unaffected by the micro-algal samples. The most promising micro-algal strain was found to be Chlorella saccharophila CCAP211/48, as its extracts inhibited quorum sensing-regulated gene expression in all three reporter strains. |
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