| one publication added to basket [121606] | Sea anemone venom as a source of insecticidal peptides acting on voltage-gated Na+ channels
In: Toxicon. Elsevier: Oxford. ISSN 0041-0101; e-ISSN 1879-3150, meer
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| Trefwoorden |
Aquatic organisms > Marine organisms > Aquatic animals > Marine invertebrates
Biological phenomena > Evolution
Biology > Physiology > Animal physiology
Cells > Receptors
Chemical compounds > Organic compounds > Proteins > Peptides
Fauna > Aquatic organisms > Aquatic animals > Aquatic insects
Materials > Hazardous materials > Biological poisons
Materials > Hazardous materials > Biological poisons > Neurotoxins
Pesticides > Insecticides
Toxins
Actiniaria [WoRMS]
Marien/Kust |
| Author keywords |
sea anemone; voltage-gated sodium channel; insecticide; toxin; site 3;ATX-II |
| Auteurs | | Top |
- Bosmans, F.
- Tytgat, J., meer
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| Abstract |
Sea anemones produce a myriad of toxic peptides and proteins of which a large group acts on voltage-gated Na+ channels. However, in comparison to other organisms, their venoms and toxins are poorly studied. Most of the known voltage-gated Na+ channel toxins isolated from sea anemone venoms act on neurotoxin receptor site 3 and inhibit the inactivation of these channels. Furthermore, it seems that most of these toxins have a distinct preference for crustaceans. Given the close evolutionary relationship between crustaceans and insects, it is not surprising that sea anemone toxins also profoundly affect insect voltage-gated Na+ channels, which constitutes the scope of this review. For this reason, these peptides can be considered as insecticidal lead compounds in the development of insecticides. |
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