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Involvement of cyclic nucleotides and IP3 in the regulation of luminescence in the brittlestar Amphipholis squamata (Echinodermata)
De Bremaeker, N.; Dewael, Y.; Baguet, F.; Mallefet, J. (2000). Involvement of cyclic nucleotides and IP3 in the regulation of luminescence in the brittlestar Amphipholis squamata (Echinodermata). Luminescence 15(3): 159-163. https://dx.doi.org/10.1002/1522-7243(200005/06)15:3<159::AID-BIO581>3.0.CO;2-P
In: Luminescence. Wiley: Chichester, Sussex, UK. ISSN 1522-7235; e-ISSN 1522-7243, meer
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  • De Bremaeker, N.
  • Dewael, Y.
  • Baguet, F., meer
  • Mallefet, J., meer
Abstract
    We investigated the effects of cyclic nucleotides (cGMP, cAMP) and the phosphoinositide IP3 on the luminescence of the ophiuroid Amphipholis squamata. The cGMP analogue, dibutyryl-cGMP, and the guanylate cyclase activator, sodium nitroprusside, had no effect on the luminescence. The cAMP analogue, dibutyryl-cAMP, and the adenylate cyclase activator, forskolin, triggered luminescence. Moreover, the adenylate cyclase inhibitor, MDL-12330A, significantly reduced ACh-induced luminescence. The phospholipase C inhibitor, U-73122, also significantly reduced ACh-induced luminescence. The results suggest that ACh-induced luminescence is mediated by both cAMP and IP3 pathways but not by cGMP. The effects of calcium-free ASW confirmed this hypothesis. A hypothetical scheme of the transduction mechanisms involved in the intracellular control of luminescence is presented.
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