Pseudochelin A, a siderophore of Pseudoalteromonas piscicida S2040
Sonnenschein, E.C.; Stierhof, M.; Goralczyk, S.; Vabre, F.M.; Pellissier, L.; Hanssen, K.O.; de la Cruz, M.; Diaz, C.; de Witte, P.; Copmans, D.; Andersen, J.H.; Hansen, E.; Tormo, J.R.; Ebel, R.; Milne, B.F.; Deng, H.; Gram, L.; Jaspars, M.; Tabudravu, J.N. (2017). Pseudochelin A, a siderophore of Pseudoalteromonas piscicida S2040. Tetrahedron 73(18): 2633-2637. https://dx.doi.org/10.1016/j.tet.2017.03.051
In: Tetrahedron. Pergamon Press: New York; Oxford; Paris; Frankfurt. ISSN 0040-4020; e-ISSN 1464-5416, meer
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| Trefwoord |
Pseudoalteromonas Gauthier, Gauthier & Christen, 1995 [WoRMS]
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| Author keywords |
Pseudoalteromonas; Siderophore; Pseudochelin A; NMR; LCMS |
| Auteurs | | Top |
- Sonnenschein, E.C.
- Stierhof, M.
- Goralczyk, S.
- Vabre, F.M.
- Pellissier, L.
- Hanssen, K.O.
- de la Cruz, M.
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- Diaz, C.
- de Witte, P., meer
- Copmans, D., meer
- Andersen, J.H.
- Hansen, E.
- Tormo, J.R.
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- Ebel, R.
- Milne, B.F.
- Deng, H.
- Gram, L.
- Jaspars, M.
- Tabudravu, J.N.
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| Abstract |
A new siderophore containing a 4,5-dihydroimidazole moiety was isolated from Pseudoalteromonas piscicida S2040 together with myxochelins A and B, alteramide A and its cycloaddition product, and bromo- and dibromoalterochromides. The structure of pseudochelin A was established by spectroscopic techniques including 2D NMR and MS/MS fragmentation data. In bioassays selected fractions of the crude extract of S2040 inhibited the opportunistic pathogen Pseudomonas aeruginosa. Pseudochelin A displayed siderophore activity in the chrome azurol S assay at concentrations higher than 50 μM, and showed weak activity against the fungus Aspergillus fumigatus, but did not display antibacterial, anti-inflammatory or anticonvulsant activity. |
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