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White sided dolphin metallothioneins: purification, characterisation and potential role
Das, K.; Jacob, V.; Bouquegneau, J.-M. (2002). White sided dolphin metallothioneins: purification, characterisation and potential role. Comp. Biochem. Physiol. 131(3): 245-251. https://dx.doi.org/10.1016/S1532-0456(02)00011-X
In: Comparative Biochemistry and Physiology. Pergamon Press: London; New York. ISSN 0010-406X, meer
Peer reviewed article  
Beschikbaar in  Auteurs 
Trefwoord
    Marien/Kust
Author keywords
    marine mammals; Lagenorhynchus acutus; white-sided dolphin; heavymetals; cadmium; metallothioneins; isoforms
Auteurs  Top 
  • Das, K., meer
  • Jacob, V.
  • Bouquegneau, J.-M., meer
Abstract
    Metallothioneins (MTs) were characterised in the kidneys of a white-sided dolphin Lagenorhynchus acutus stranded along the Belgian coast, displaying high levels of cadmium (Cd) and mercury (Hg) in liver and kidney. The protein has two isoforms: MT-1 and MT-2. MT-1 binds Cu, Zn, Hg and Cd, while MT-2 only binds Zn, Hg and Cd. This suggests different metabolic functions for the two isoforms: MT-1 is mainly involved in Cu homeostasis; MT-2, which was fourfold more abundant than MT-1, detoxifies most of the accumulated cadmium.
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